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Now, three researchers at the University of Pennsylvania, Alexander Platt, Daniel N. Harris, and Sarah Tishkoff, have done the converse analysis: examining the X chromosomes of the handful of completed Neanderthal genomes we have. It turns out there's also a strong bias toward modern human sequences there, as well, and the authors interpret that as selective mating, with Neanderthal males showing a strong preference for modern human females and their descendants.
This fragmentation hurts portability. Code that performs well on one runtime may behave differently (or poorly) on another, even though it's using "standard" APIs. The complexity burden on runtime implementers is substantial, and the subtle behavioral differences create friction for developers trying to write cross-runtime code, particularly those maintaining frameworks that must be able to run efficiently across many runtime environments.